Author: Times Wang

I am a scientist on stem cell R&D, including generation of iPS cells and isolating MSC form blood, bone marrow, adipose, etc. and applying stem cell therapy for type 1 diabetes, Parkinson's disease, amyotrophic lateral sclerosis, Alzheimer's disease, cancer and osteoarthritis, heart disease, stroke, burns, etc.
Times Wang

PAPERS:

  1. Hongran Wang, Shuying Zhao, Richard H. Finnell, Timothy George and Austin J. Cooney. Genetation of Integration-free iPSCs from a patient with spina bifida. Stem Cell Research. 2018 (in press).
  2. Hongran Wang, Michelle Barton, Todd Rosengart and Austin J. Cooney. Reciprocity of Action of Increasing Oct4 and Repressing p53 in Transdifferentiation of Mouse Embryonic Fibroblasts into Cardiac Myocytes. Cell Reprogram. 2018 Feb;20(1):27-37.
  3. Hongran Wang, Yutao Xi, Yi Zheng, Xiaohong Wang and Austin J. Cooney. Generation of Electrophysiologically Functional Cardiomyocytes from Mouse Induced Pluripotent Stem Cells. Stem Cell Research. 2016, 16 (2): 522–530.PMC4828332.Full Article
  4. Hongran Wang, Xiaohong Wang, Xueping Xu, Michael Kyba, Austin J. Cooney. Germ Cell Nuclear Factor (GCNF) Represses Oct4 Expression and Globally Modulates Gene Expression in Human Embryonic Stem (hES) Cells. J Biol Chem. 2016, 291(16):8644-52.PMC4861434.Full Article
  5. Hongran Wang, Pluripotent Stem Cells and Repair of Myocardial Infarction, Trop Med Surg 2015, 3:1 http://dx.doi.org/10.4172/2329-9088.1000181
  6. Hongran Wang, Induced Pluripotent Stem Cells and Heart Failure Therapy. Int J Surg Res Pract. 2014, 1:001e.
  7. Wei-Wei Bi, Wei-Hua Zhang, Gui-Hua Yin, Hong Luo, Shou-Qin Wang, Hongran Wang, Chao Li, Wei-Qun Yan, De-Zhi Nie. Analysis of indoleamine 2-3 dioxygenase (IDO) and EGFR co-expression in breast cancer tissue by immunohistochemistry. Asian Pac J Cancer Prev. 2014;15(14):5535-5538.PMID: 25081660.Full Article
  8. Hongran Wang, Xiaohong Wang, Trevor Archer, Thomas Zwaka and Austin J. Cooney, Gcnf-dependent activation of cyclin d1 expression via repression of mir-302 during ESC differentiation, Stem Cells. 2014, 32(6):1527-1537.
  9. Deepavali Chakravarti, Xiaohua Su, Min Soon Cho, Ngoc Hoang Bao Bui, Cristian Coarfa, Avinashnarayan Venkatanarayan, Ashley L. Benham, Ramón E. Flores González, Jennifer Alana, Weimin Xiao, Marco L. Leung, Harina Vin, Io Long Chan, Arianexys Aquino, Nicole Müller, Hongran Wang, Austin J. Cooney, Jan Parker-Thornburg, Kenneth Y. Tsaig, Preethi H. Gunaratne, and Elsa R. Flores. Induced multipotency in adult keratinocytes through down-regulation of ΔNp63 or DGCR8. Proc Natl Acad Sci U S A. 2014, 111(5):E572-581.
  10. Hongran Wang, Xiaohong Wang, Xueping Xu, Thomas Zwaka and Austin J. Cooney. Epigenetic re-programming of the Germ Cell Nuclear Factor gene is required for proper differentiation of induced pluripotent cells. Stem Cells, 2013 ,31: 2659-2666.
  11. Jayantha B. Tennakoon, Hongran Wang*, Cristian Coarfa, Aleksandar Milosavljevic, Austin J. Cooney, Preethi H. Gunaratne, Loss of Dicer results in a shift in transcriptionally favorable and unfavorable histone marks to influence genes in embryonic stem cells，Plos One, 2013 Sep 9;8(9):e74556. (* co-first author).
  12. Jian Min Deng, Kei Satoh, Hongran Wang, Hao Chang, Zhaoping Zhang, M. David Stewart, Austin J. Cooney and Richard R. Behringer. Generation of Viable Male and Female Mice from Two Fathers, Biol Rrprod, 84: 613–618 , 2011.
  13. Hongran Wang, Xueping Xu, Austin Cooney. Germ cell nuclear factor (gcnf) represses the oct4 gene during retinoic acid-induced human embryonic stem cell differentiation. Biol Reprod, 77(Suppl_1):218-219, 2007
  14. Wang Hong, Wang Xiaohong, Zheng Ruizhen. Stem cell and repair of injury in central nervous system. Journal of biomedical engineering. J. Biomed. Eng. 2006, 6: 1359-1362.
  15. Wang Hong, Zheng Ruizhen, Wang Xiaohong, et al. Development of fibroblasts and embryonic stem cells within enucleated oocytes of mouse and rabbit. Journal of Dalian University of Technology, 2006,46(2):185-189.
  16. Lei Lei, Liu Zhong Hua1, Wang Hong, Kou Zhao Hui , Wu YuQi1 , Xu Ying1 ,Cheng Yong , Zhu Ziyu, Xia Guo Liang , Cheng Dayuan ,The Effects of Different Donor Cells and Passages on Development of Reconstructed Embryos. Acta Genetica Sinica , 2003, 30:215-220.
  17. Wang Hong, Zheng Ruizhen, Lian Li, Xu Ying, An Lijia,& Chen Dayuan. Effects of 6-DMAP and Passages of embryonic stem cells on the development in vitro of interspecific reconstructed oocytes. Acta Biologiae Experimentalis Sinica, 2003, 36(2): 145-148.
  18. Wang Hong, Zheng Ruizhen, Xu Ying, Lian Li, An Lijia,& Chen Dayuan. Embryonic stem cell as nuclear donor could promote in vitro development of the heterogeneous reconstructed embryo. Chinese Science Bulletin. 2002, 47(21): 1811-1815.
  19. Wang Hong, Zheng Ruizhen, An Lijia. Therapeutic Cloning, Progress in Biotechnology. 2002, 22:29-34.
  20. Wang Hong, Zheng Ruizhen. The effects of several factors on the isolation of ES cells from the ICM of Kuming Albio mouse. Second international symposium on angiogenesis and hematopoiesis. 2000 1,9.
  21. Wang Hong, Dong Heyan, Wang Xiaohong, Wang Qinfu, Yang Tingbin. Effect of super-heat isomeric endotoxin on withdrawal of morphine addictive mice, U.S.Chinese Health and Hygiene Journal, 1999, 2: 9-10.
  22. Wang Hong, Dong Heyan, Wang Xiaohong, Wang Qinfu, Yang Tingbin. Effect of super-heat isomeric endotoxin on withdrawal of morphine addictive mice, U.S.Chinese Health and Hygiene Journal, 1999, 2: 9-10.
  23. Wang Xiaohong, Wang Hong, Feng Zhongmin, Kuang Hongxing. The anti-tumor function of 70KD heat shock protein of salmonella thphi. Journal of Dalian University, 1999, 20: 80-82.
  24. Wang Hong, Wang Qinfu, Wang Xiaohong, Zhao Caihong, Yang Tingbin, Wang Xiaohui. The effect of the super-heat isomeric endotoxin on the weight of morphine addictive mice after withdrawal, Journal of Dalian University. 1999, 20: 73-75.
  25. Wang Hong, Yang Tingbin, Chen zhangquan, Miao xiaoyan, Wang xiaohong. The diagnostic significance of detecting 65KD heat shock protein antibody for type I diabetes mellitus, Chinese Journal of Diabetes, 1998,6;18-20.
  26. Wang Hong, Yang tingbin, Chen zhangquan, Miaoxiaoyan, Zhao Cahong, Wang xiaohong, Liang Ping, Immunopathologic effect of BCG 65 KD heat shock protein on type I diabetes mellitus, Chinese Journal of Immunology, 1998, 14(supl): 236-239.
  27. Wang Hong, ZhaoCaihong, Sun Li, Wang Qifu, Yu Zhengguo, Zhang Dan, Wang Xiaohong.Establishing the model of morphine addictive mice. Journal of Dalian University 1998, 19: 84-86.
  28. Wang Hong, Determination of the optimal conditions of detecting 64KD antibody in serum with the insulin dependent diabetes patients by ELISA. Journal of Dalian University, 1997, 7:95-97.
  29. Wang Hong, Yang Tingbin, Chen Zhangquan, Miao Xiaoyan, Wang Xiaohong, Establishing method of detecting 64000 protein antibody of pancreatic islet cell by ELISA, Chines Journal of Medical Laboratory Sciences. 1997, 20: 284.

MEETING ABSTRACTS:

  1. Hongran Wang, XuePing Xu, Xiaohong Wang, Ryan Wagner and Austin J. Cooney. Mir302 regulates the proliferation of ES cells via Cyclin D1. 4th Annual M. D. Anderson/Baylor College of Medicine Symposium. January 22,2009, Houston Texas.
  2. Hongran Wang, XuePing Xu, Xiaohong Wang, Ryan Wagner and Austin J. Cooney. Cyclin D1 and mir 302 co-regulate the proliferation of ES cells. Center for cell and gene therapy 2008 conference November 10th and 11th, 2008 Houston, Texas.
  3. Hongran Wang, XuePing Xu and Austin J. Cooney. Germ Cell Nuclear Factor Represses the Oct4 Gene During Retinoic Acid- Induced Human Embryonic Stem Cell Differentiation. 6th Annual Meeting of the International Society for Stem Cell Research June 11-14, 2008,Pennsylvania Convention Center, Philadelphia, USA.
  4. Hongran Wang, XuePing Xu and Austin J. Cooney. Germ Cell Nuclear Factor (GCNF) Represses the Oct4 Gene During Retinoic Acid- Induced Human Embryonic Stem Cell Differentiation. 40th Annual Meeting of the Society for the Study of Reproduction
21–25 July 2007,San Antonio, Texas.
  5. Hongran Wang, Austin Cooney.Germ Cell Nuclear Factor (GCNF) Represses the Oct4 Gene During Retinoic Acid- Induced Human Embryonic Stem Cell Differentiation(submitted). 59th Annual Symposium on Fundamental Cancer Research:Stem Cells in Cancer and Regenerative Medicine. Houston, TX . Oct. 2006
  6. Wang Hong, Zheng Ruizhen. The effects of several factors on the isolation of ES cells from the ICM of Kuming Albino mouse. 2th international symposium on angiogenesis and hematopoiesis. Tianjin, China Aug 31th-Sep 3rd.2001